english.prescrire.org > Spotlight > Archives : 2021 > In the November issue of Prescrire International: adverse effects of growth hormone and of thiazide diuretics

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In the November issue of Prescrire International: adverse effects of growth hormone and of thiazide diuretics

FREE DOWNLOAD In the "Adverse effects" section this month, Prescrire reports on the cardiovascular effects of growth hormone, and on ocular adverse effects of thiazide diuretics.
Full text available for free download.

Growth hormone: cardiovascular events in young adults

  • The results of a Swedish cohort study have shown a link between treatment with growth hormone (somatropine) in childhood and the occurrence of cardiovascular events in early adulthood.
     
  • These adverse effects in adulthood should be taken into account when deciding whether or not to use somatropin, all the more so because in the case of idiopathic growth hormone deficiency, there is only a modest gain in adult height.

Thiazide diuretics: choroidal effusion and acute myopia

  • In 2020, the European Medicines Agency (EMA) decided to include choroidal effusion as an adverse effect in the summaries of product characteristics (SPCs) for medicines containing thiazide and thiazide­-like diuretics.
     
  • Choroidal and ciliochoroidal effusions due to thiazide diuretics cause bilateral myopia of rapid onset and a risk of acute angle-­closure glaucoma.
     
  • If visual disorders develop rapidly in a patient taking a thiazide or thiazide-­like diuretic, an ophthalmological examination should be arranged without delay.
     

©Prescrire 1 November 2021

Source: Prescrire International 2021; 30 (231): 268. Free.

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