english.prescrire.org > Spotlight > Archives : 2016 > In the October issue of Prescrire International: Prucalopride (Resolor°) and chronic constipation in men

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In the October issue of Prescrire International: Prucalopride (Resolor°) and chronic constipation in men

FREE DOWNLOAD For men presenting with constipation, a troublesome but usually benign disorder, prucalopride carries a disproportionate risk of cardiovascular disorders, depression and suicidal ideation. As in women, it is better to optimise the use of standard laxatives, and to avoid prucalopride altogether.
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Summary

  • In a placebo-controlled trial in 374 men, prucalopride was only effective in a minority of cases, as previously observed in women.
     
  • In addition to its cardiovascular harms, there is evidence that prucalopride may cause depression and suicidal ideation.

Full text available for free download.

 ©Prescrire 1 October 2016

"Prucalopride (Resolor°) and chronic constipation in men. Avoid in both men and women." Prescrire Int 2016; 25 (175): 234. (Pdf, free)
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