english.prescrire.org > Spotlight > Archives : 2017 > In the January issue of Prescrire International: adverse effects of pseudoephedrine and sofosbuvir

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In the January issue of Prescrire International: adverse effects of pseudoephedrine and sofosbuvir

FREE DOWNLOAD In the "Adverse Effects" section of this month's issue, ischaemic colitis with the decongestant pseudoephedrine, and a risk of pulmonary arterial hypertension with the hepatitis C drug sofosbuvir.
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Pseudoephedrine: ischaemic colitis

  • Sympathomimetic vasoconstrictors can provoke neurological and cardiovascular adverse effects, including hypertensive crisis, stroke and arrhythmia. A few cases of localised colonic ischaemia have been reported
     
  • There is no justification for using drugs capable of provoking ischaemic events, with potentially serious or even fatal consequences, simply to alleviate a few transient and complication-free symptoms of the common cold. 

Sofosbuvir: pulmonary arterial hypertension?

  • The serious adverse drug reactions reported in France with sofosbuvir for the treatment of hepatitis C include 7 cases of pulmonary arterial hypertension (PAH).
     
  • Very little research was conducted on the adverse effects of sofosbuvir before its market introduction. Healthcare professionals must pay attention to events that occur during treatment and report them

Full text available for free download.

 ©Prescrire 1 January 2017

Prescrire Int 2017; 26 (178): 20. (Pdf, free)

 

 
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