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2019 : 1 | 30 | 60

In the March issue of Prescrire International: Minor ischaemic stroke and antiplatelet drugs

FREE DOWNLOADIn this month's free sample text, the results of a trial confirming that after a minor stroke or transient ischaemic attack there is very little advantage from adding clopidogrel to aspirin, which remains the first-choice antithrombotic. 
Full text available for free download.

Summary

  • In a double-blind, randomised trial, adding clopidogrel to aspirin after a minor ischaemic stroke or transient ischaemic attack reduced the risk of recurrent ischaemic stroke, but had no demonstrated effect on mortality or disability.
     
  • After one month of dual therapy, the incidence of ischaemic events (mainly strokes) fell from 5.8% with aspirin alone to 3.9% with dual therapy. Increasing the duration of clopidogrel administration to 3 months did not result in any greater efficacy whereas it increased the risk of haemorrhage.

Full text available for free download.

 ©Prescrire 1 March 2019

"Minor ischaemic stroke and antiplatelet drugs. Very little advantage from adding clopidogrel to aspirin" Prescrire Int 2019; 28 (202): 77. (Pdf, free).

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