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In the March issue of Prescrire International: polatuzumab vedotin (Polivy°) and large B-cell lymphoma

FREE DOWNLOADPolatuzumab vedotin has been granted conditional European marketing authorisation for certain patients with relapsed or refractory diffuse large B-cell lymphoma. How do Prescrire's editors rate this option?
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  • Polatuzumab vedotin (Polivy°) as an adjunct to bendamustine + rituximab has been granted conditional European marketing authorisation for use in adults with relapsed or refractory diffuse large B-cell lymphoma who are not candidates for haemopoietic stem cell transplantation.
     
  •  NOT ACCEPTABLE  A single randomised comparative trial with numerous methodological flaws evaluated the addition of polatuzumab vedotin to a drug combination which is relevant in this situation.

©Prescrire 1 March 2021

Source: "Polatuzumab vedotin (Polivy°) and large B-cell lymphoma" Prescrire International 2021; 30 (224): 65. Free.

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