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Pregabalin during the first trimester of pregnancy: probably a slight increase in major malformations

 Adverse Effects   New pharmacoepidemiological data show a higher incidence of various major congenital malformations following in­-utero exposure to pregabalin than in control groups. What is the evidence for this risk, and what are the consequences in practice?
Full article available for download by subscribers (2 pages)

©Prescrire 1 May 2024

Source: "Pregabalin during the first trimester of pregnancy: probably a slight increase in major malformations" Prescrire Int 2024; 33 (259): 128-129. Subscribers only.

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See also:

"Pregabalin or gabapentin
during pregnancy: take
their known dangers
and uncertainties into account"
Prescrire Int 2020;
29 (215): 127-129.
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"Pregabalin: avoid its use
for focal seizures and
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just as for neuropathic pain"
Prescrire Int 2024;