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Long-term PPI treatment: increased incidence of gastric cancer and gastric cancer recurrence

 Adverse Effects  In 2023, in two cohort studies including about 300 000 patients who had received at least one treatment for Helicobacter pylori infection, the risk of gastric cancer was about 4-fold greater in patients with the most exposure to PPIs than in those who had little or no exposure. 
Full article available for download by subscribers

 ©Prescrire 1 September 2025

Source: "Long-term PPI treatment: increased incidence of gastric cancer and gastric cancer recurrence" Prescrire Int 2025; 34 (273): 215-216. Subscribers only.

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See also:

"Proton pump inhibitors:
increased mortality"
Prescrire Int 2019;