english.prescrire.org > Spotlight > Archives : 2016 > In the November issue of Prescrire International: More on domperidone and sudden cardiac death. French opinion leaders and regulators in the hot seat

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In the November issue of Prescrire International: More on domperidone and sudden cardiac death. French opinion leaders and regulators in the hot seat

FREE DOWNLOAD In a letter to Prescrire's editors, the lead author of a study on the number of deaths attributable to domperidone answers critiques that appeared in the French news media after the publication of the study.
Full text available for free download.

Summary

  • According to Prescrire's evaluation of domperidone, it is a "drug to avoid".
     
  • In 2014 Prescrire published an article in which it estimated that between 25 and 120 deaths in France in 2012 were attributable to domperidone. The full study was then published in Pharmacoepidemiology and Drug Safety in 2015, with a final estimate for the year 2012 of about 230 deaths in the population aged 18 years or over.
     
  • The study was led by Catherine Hill, an epidemiologist at the Institut Gustave Roussy (France). Following criticisms of the findings by opinion leaders in the French news media, she invited a scientific debate within the journal where the study was initially published.
     
  • A year later, no scientific criticism has arrived. She has therefore decided to answer the criticisms levelled against the study in the lay media, in a letter to Prescrire's editors.

Full text available for free download.

 ©Prescrire 1 November 2016

"Letter to Prescrire's Editors. More on domperidone and sudden cardiac death. French opinion leaders and regulators in the hot seat" Prescrire Int 2016; 25 (176): 278-279. (Pdf, free)
Download the full review
Pdf, free

See also:
 
Drugs to avoid, in the name
of better patient care:
2016 update
(February 2016)
Free

Metoclopramide, domperidone:
sudden cardiac death,
ventricular arrhythmia
(October 2016)
Free

Nausea and vomiting:
stop the use of domperidone
once and for all
(February 2014)
Free

Domperidone should not
be used: 9 articles from
Prescrire's ongoing analysis
(February 2014)
Free