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• Domperidone should not be used: 9 articles from Prescrire's ongoing analysis

Prescrire has followed and regularly updated its analysis of domperidone (Motilium° or other brands). The injectable form was withdrawn from the market in 1986 following serious cardiac rhythm disorders, some fatal. Since then, the profile of cardiac adverse effects of the oral forms of domperidone has become clearer: this drug should not be used.

Below is a selection of the reviews published in Prescrire's English edition since 2002.

Domperidone and cardiac disorders: avoid this neuroleptic
Prescrire International 2013; 22 (144): 297.  
> Pdf, subscribers only

Domperidone and cardiac disorders: this drug should be withdrawn now
(December 2013)
> Free

Domperidone: ventricular arrhythmia and sudden death (continued)
Prescrire International 2012; 21 (129): 183.
> Pdf, subscribers only

In the July issue of Prescrire International: domperidone should be avoided
(July 2012)
> Free

Domperidone: QT prolongation in infants
Prescrire International 2011; 20 (112): 14.
> Pdf, free

In the January issue of Prescrire International:
Domperidone - QT prolongation in infants
(January 2011)
> Free

Domperidone and sudden death
Prescrire International 2008; 17 (94): 67.
> Pdf, subscribers only
     
Domperidone and sudden death
Prescrire International 2006; 15 (86): 226.
> Pdf, subscribers only     

Severe ventricular arrhythmia and sudden death on neuroleptics
Prescrire International 2002; 11 (61): 146-150.
> Pdf, subscribers only

©Prescrire 19 February 2014
See also:

Nausea and vomiting:
stop the use of domperidone
once and for all
(February 2014)
Free