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Zonisamide: as dangerous as topiramate during pregnancy?

 Adverse Effects  The EMA has concluded that a pregnancy test should be "considered" before initiating treatment with zonisamide. Its close pharmacological similarity to topiramate, which has established teratogenic effects, plus the few available data, indicate the need for caution in women who are, or could become, pregnant.
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EDITORS' OPINION
Beyond the SmPC

A drug's effects on pregnancy and the unborn child are often poorly documented. It can take decades to know whether a drug is relatively safe to use during pregnancy, whether the risks are acceptable provided certain precautions are taken, or whether it should be avoided...

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©Prescrire 1 December 2023

Source: "Zonisamide: as dangerous as topiramate during pregnancy?" Prescrire Int 2023; 32 (254): 300-301. Subscribers only.

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See also:
"Topiramate during pregnancy:
autism and intellectual disability
in children (continued)"
Prescrire Int 2023;
32 (246): 78.
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"Zonisamide. No advantage
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