april fool's! Alert readers the world over will have recognised that the item in the April issue of La revue Prescrire entitled "Pay-for-talk" – although better communications with healthcare professionals would certainly pay off for patients – was in fact an April fool's prank.

3 Decades of "fishy business" in April
The traditional April prank by Prescrire's editors serves as an annual "booster shot" to remind us all that in the serious business of medical information, it pays to exercise critical judgement at all times.

In April 1983 Prescrire's "special correspondent" revealed to enthralled readers the enormous interest of protryptophane in the treatment of acute senility... And ever since, the experiment has been repeated yearly in La revue Prescrire's April issue.

In 2003 Prescrire's "April fish" (as the seasonal pranks are known in France) even made it into the English edition, Prescrire International. It's included below, in a sampling of Prescrire's yearly "Poissons d'avril".

Greatest hits from Prescrire's annual "Poisson d'avril" prank

• ADR: a new global phenomenon, thanks to the ICH (1 April 2013)
  "French journal Prescrire reports unbelievable news regarding the creation of the worldwide Agency for Drug Reconciliation (ADR)..." 
  "ADR: a new global phenomenon, thanks to the ICH" Prescrire Int 2013; 22 (137): 88. (Pdf, free).
  
  
• A new drug treatment makes headlines in France: olanzapine + topiramate (Obéfix°), maintains ideal weight without risk (1 April 2012)
  "La Revue Prescrire has revealed unbelievable new results that will be welcome reading for medical professionals and patients alike. ..." 
  "Olanzapine + topiramate (Obéfix°)" Rev Prescrire 2012; 33 (342: 248-251. (pdf in French, free)
> Online news item in English (April 2012). Free

• Doing away with adverse effects (1 April 2011) 
  "A modest proposal from the Informal Collusion for Hypermedicamentation (ICH)...." 
  "En finir avec les effets indésirables" Rev Prescrire 2011; 31 (330): 295. (pdf in French, free)
  
  
• Prostate transplants: too many deaths (1 April 2009)
  "In practice, it is best not to encourage patients to undergo a prostate transplant. And to read Prescrire with a critical eye... "
  "Greffes de prostate : trop de décès" Rev Prescrire 2009; 29 (306): 268. (pdf in French, free)
   
• Dextrodénafil // lévoxétine (Libidossil°) (1 April 2006)
  "Drug-based dissociation of erectile dysfunction: a double me-two fantasy"
  "dextrodénafil // lévoxétine (Libidossil°)" Rev Prescrire 2006; 26 (271): 251. (pdf in French, free)

•  IN ENGLISH  Tour de France: ads in the saddle! (1 April 2003)
  "In case Credit Lyonnais pulls out of Tour de France sponsorship, negotiations with the French pharmaceutical federation are nearing completion... Companies manufacturing growth hormones and erythropoietin, have opted for the spotted jersey for the best climber..."
  "Tour de France: ads in the saddle!" Prescrire Int 2003; 11 (66): 307. (pdf, free)

• The 2001 "Golden Microphone" awards
  for the pharmaceutical industry (1 April 2001)
  "The drug industry shows that it knows how to show its gratitude to deserving "opinion leaders"..." 
  "Les micros d'Or 2001 de l'industrie pharmaceutique"  Rev Prescrire 2001; 21 (216): 307. (pdf in French, free)
  
  
• Diffunase° (1 April 2000)
  "Prevention of stress, of sexual dysfunction, of insomnia, primal urges, bulimia, etc. All by a very novel means of administration: air travel."
  "Gamme Diffunase°, n'importe quoi !"  Rev Prescrire 2000; 20 (205): 266-268. (pdf in French, free)
  
  
• The French medicines agency and the Y2K bug (1 April 1999)
  "For the most difficult months, until approximately 1 April 2000, we will be using an amazing team of carrier pigeons that was recently retired from the armed services. I would like to particularly thank the National Pharmaceutical Association which once again provided financial assistance..."
  "L'Agence française du médicament et le bogue de l'an 2000" Rev Prescrire 1999; 19 (194): 308. (pdf in French, free)
  
  
• A computerised medical information system in France? (1 April 1997)
  "A confidential report by the Ministries of Health and Finance contains a proposal for a mandatory computerised medical identification system, in the form of an unremovable computerised bracelet to be worn by all beneficiaries of the national health insurance system..."  
  "Un carnet de santé informatisé en France ?" Rev Prescrire 1997; 17 (172): 284 - 285 et 308. (pdf in French, free)
  
  
• Panaceum° tablets (1 April 1984)
  "All the results are unanimous, just a single 5 mg dose is enough to cure the great majority of illnesses. The huge advantage for us prescribers is that there is no need for a precise diagnosis. As soon as we suspect some disorder, major or minor, no matter what it involves, the prescription is the same..."
  "Panaceum° comprimés" Rev Prescrire 1984; 4  (34) : 2. (pdf in French, free)
  "Panaceum° d'avril" Rev Prescrire 1984 ; 4  (35): II. (pdf in French, free)
  
  
• Kwajalumpur. 3rd Symposium of the International Federation of Experimental Gerontopathology: protryptophane can cure senility (1 April 1983)
  "The press must be ever alert in order to satisfy readers' thirst for news..."
  "Kwajalumpur. Troisième symposium de la Féderation Internationale de Gérontopathologie Expérimentale : le protryptophane peut guérir la sénilité" Rev Prescrire 1983; 3 (24): 13 - 14. (pdf in French, free)
  

©Prescrire 1 April 2015