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In the October issue of Prescrire International: Prucalopride (Resolor°) and chronic constipation in men

FREE DOWNLOAD For men presenting with constipation, a troublesome but usually benign disorder, prucalopride carries a disproportionate risk of cardiovascular disorders, depression and suicidal ideation. As in women, it is better to optimise the use of standard laxatives, and to avoid prucalopride altogether.

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Summary

In a placebo-controlled trial in 374 men, prucalopride was only effective in a minority of cases, as previously observed in women.
In addition to its cardiovascular harms, there is evidence that prucalopride may cause depression and suicidal ideation.

Full text available for free download.

"Prucalopride (Resolor°) and chronic constipation in men. Avoid in both men and women." Prescrire Int 2016; 25 (175): 234. (Pdf, free)

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