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In the January issue of Prescrire International: Primary prevention of cardiovascular disease

FREE DOWNLOAD This month's sample page from the Reviews section makes the point that statins and hypotensive drugs ought not necessarily to be prescribed for everyone who may be at risk.
Full text available for free download.

Summary

  • In a large-scale placebo-controlled trial, about 13 000 patients at risk of a first cardiovascular event were followed for approximately six years.
     
  • Low-dose rosuvastatin and the combination of candesartan + hydrochlorothiazide did not reduce total mortality or cardiovascular mortality.
     
  • These findings do not justify routinely exposing all patients at cardiovascular risk due to tobacco use or family history to the adverse effects of these drugs.

Full text available for free download.

 ©Prescrire 1 January 2018

"Primary prevention of cardiovascular disease Statins and hypotensive drugs: not for everyone" Prescrire Int 2018; 27 (189): 24. (Pdf, free)
Download the full review
Pdf, free