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Dapivirine vaginal ring in the prevention of HIV

 Marketing Authorisations  Fragile data from a single clinical trial suggest that the dapivirine vaginal ring has at best partial efficacy in the prevention of HIV infection, with a considerable margin of uncertainty.
Full article (4 pages) available for download by subscribers.

  • When considering drug-based prophylaxis to prevent HIV infection, a vaginal device left in place for 4 weeks that releases an antiretroviral drug could be of value to some women, especially when pre-exposure prophylaxis (PrEP) with oral emtricitabine + tenofovir is not a suitable option. But the efficacy of the intravaginally released drug would have to be established, which is not the case for the dapivirine vaginal ring as of 2022.
     
  • Based on the data available, its evaluation should be continued.

©Prescrire 1 December 2022

Source: "Dapivirine vaginal ring in the prevention of HIV" Prescrire International 2022; 31 (243): 285-288. Subscribers only.

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