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Pregabalin and gabapentin: sometimes fatal overdoses

 Adverse effects   Various studies have confirmed that pregabalin overdose carries a risk of coma and respiratory depression. The risk of overdose is increased in patients with renal impairment. The severity of such overdoses is increased when pregabalin is combined with a central nervous system depressant such as an opioid. Gabapentin also carries a risk of overdose in the presence of renal impairment.
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Pregabalin: avoid its use for focal seizures and generalised anxiety disorder, just as for neuropathic pain

Based on the data available in 2023, there are better options than pregabalin for focal seizures and generalised anxiety disorder, just as there are for neuropathic pain...

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©Prescrire 1 March 2024

Source: "Pregabalin and gabapentin: sometimes fatal overdoses" Prescrire Int 2024; 33 (257): 72-74. Subscribers only.

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See also:

"Pregabalin: very similar
to gabapentin"
Prescrire Int 2005;
14 (80): 203-206.
Subscribers only


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